Welcome To AcelaBio. Histopathology & Precision Medicine Services
AcelaBio is a state-of-the-art contract research organization delivering end-to-end histopathology and precision medicine laboratory services for pharmaceutical, biotech, and academic institutions.
AcelaBio's expert team is made up of operational, scientific, and medical experts, including U.S. Board Certified pathologists, dedicated to delivering reliable, high-quality data and imagery.
As a CAP-accredited laboratory, AcelaBio has rigorous policies and procedures for optimizing and validating assays to ensure high-quality laboratory testing and patient safety.
AcelaBio provides high throughput digital pathology services to support multicenter, global clinical trials and has the flexibility to develop and validate biomarker assays for novel or existing protein or molecular targets.
Expert Tissue Analysis
From Sample to Score
End-to-end Seamless Workflows
Wet Lab
Dry Lab
At AcelaBio, we offer in-depth, end-to-end tissue analysis from sample to score to accelerate biomarker discovery and development. Combining state-of-the-art laboratory facilities with advanced computational analysis, we achieve reliable, consistent, and high-quality results. From wet lab to dry lab, we seamlessly turn tissue samples into images, images into data, and data into insights. Trust us to bring your research to the next level.
- Expert tissue processing, embedding, and microtomy to control pre-analytical variables
- Consistent and reproducible automated Hematoxylin and Eosin (H&E) slide staining
- Whole slide imaging using high precision digital pathology scanner approved as a medical device
- Slide review by board-certified pathologists
- Strategic partnership to access a large network of expert pathologists with a proven track record
- 21CFR11 compliant proprietary image management software solution
- Expert tissue processing, embedding, and microtomy to control pre-analytical variables
- Consistent and reproducible automated special stains (e.g., Masson Trichrome)
- Whole slide imaging using high precision digital pathology scanner approved as a medical device
- Slide review by board-certified pathologists
- Strategic partnership to access a large network of expert pathologists with a proven track record
- 21CFR11 compliant proprietary image management software solution for slide review
- Consultative approach for target selection/identification
- Experts in IHC antibody selection, optimization, and validation
- Whole slide imaging using high precision digital pathology scanner approved as a medical device
- Quantitative digital image analysis of tissue biomarker expression using AI and deep learning techniques*
- Custom algorithm development designed to address specific and complex scientific questions with the oversight of expert board-certified pathologists*
- High-throughput analysis in whole slide images or regions of interest generating reproducible, high-quality results
*For Research Use Only (not for use in diagnostic procedures)
- Visualization of single RNA molecules in individual cells
- Unmatched sensitivity and specificity using commercially available and/or custom probes
- Automated staining for reliable and reproducible results
- Quantitative digital image analysis of RNA expression using AI and deep learning techniques*
- Custom algorithm development designed to address specific and complex scientific questions with the oversight of expert board-certified pathologists*
- High-throughput analysis in whole slide images or regions of interest generating reproducible, high-quality results
*For Research Use Only (not for use in diagnostic procedures)
- Optimized workflow for efficient RNA extraction from formalin-fixed paraffin-embedded tissue blocks or slides
- Assessment of RNA quality and quantity by automated electrophoresis
- qPCR and/or library preparation with oversight of next-generation sequencing
- Bioinformaticians with domain expertise in immunology and oncology guide the analysis process from plan to interpretation, helping you gain meaningful mechanistic insights
- Standardized bioinformatics pipeline, including QC analysis, quantitation, mapping, filtering, trimming, counting, and normalization
- In-depth analysis of differentially expressed genes and gene sets with pathway analysis and visualizations, including clustering and heatmaps
*For Research Use Only (not for use in diagnostic procedures)
- Ability to work with human or mouse formalin fixed paraffin embedded tissue blocks or slides (stained or unstained)
- Pre-qualification of samples through RNA extraction with an assessment of DV200 scores
- 10X Genomics Visium CytAssist workflow for high-resolution, reproducible results
- Library preparation, quantification, quality control, and oversight of next-generation sequencing
- A flexible, iterative three-step approach based on your study objectives to ensure you gain the most out of your spatial transcriptomics data
- Our team of experienced bioinformaticians identifies spatially resolved biomarkers, cell subtypes, and signaling pathways and provides in-depth interpretation through data integration with high-quality, curated datasets
- With our focus on quality, we diligently evaluate the quality metrics to ensure that the insights generated from the spatial transcriptomics data are robust and meaningful
*For Research Use Only (not for use in diagnostic procedures)
In Depth Analysis
Services
AcelaBio provides end-to-end histopathology and precision medicine services from "sample-to-score" for clinical trials and clinical research, including:
- Accessioning
- Processing
- Embedding
- Sectioning
- Hematoxylin & Eosin
- Special Stains
- In Situ Hybridization
- Antibody Optimization
- Assay Development
- Immunostaining
- Whole Slide Imaging
- Storage & Archiving
- Pathology Review
- Data Management
- Sample Logistics
- Consulting
- Project Management
- Clinical Trial Support
- RNA Extraction*
- Spatial Transcriptomics*
- Bioinformatics*
- Digital Image Analysis*
*For Research Use Only (not for use in diagnostic procedures)
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Therapeutic Areas
We focus on providing end-to-end histopathology and precision medicine services to support clinical research in areas of oncology, dermatology, and gastrointestinal diseases, with extensive experience in inflammatory bowel disease (IBD), nonalcoholic steatohepatitis (NASH), eosinophilic gastrointestinal diseases (EGID), and celiac disease (CeD)
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Whole Slide Images
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Projects
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Biomarkers Validated
Careers
Please find a full directory of our current opportunities below. If you do not currently see a position of interest, please visit our contact us page and send over your resume.
